Separation of 1,4-benzodiazepine Derivates by Micellar Electrokinetic Capillary Chromatography Using Cyclodextrines as Buffer Modifiers
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چکیده
منابع مشابه
Separation of 1,4-benzodiazepine Derivates by Micellar Electrokinetic Capillary Chromatography Using Cyclodextrines as Buffer Modifiers
The applicability of micellar electrokinetic capillary chromatography (MEKC) for the separation of benzodiazepine (BZD) derivates with different structural characteristics has been studied. Efforts were first focused on the optimization of the analytical conditions, on the effects of buffer concentration, surfactant concentration and buffer pH on the separation. To manipulate selectivity of the...
متن کاملSeparation of 1,4-benzodiazepine Derivates by Cyclodextrin Modified Micellar Electrokinetic Chromatography
The electrophoretic separation of electrically neutral benzodiazepines (BZDs) can be achieved by micellar electrokinetic chromatograpy (MEKC). The cyclodextrin (CD)-modified micellar electrokinetic chromatography separation of eight of the most frequently used BZD was obtained within 15 minutes at + 25 kV on a 64.5 cm x 50 μm I.D. silica capillary at 25C, using a 25 mM sodium tetraborate-50 mM ...
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The aim of this work is to elaborate a fast and reliable capillary electrophoresis method, for the separation of 1,4-benzodiazepine (BZD) derivates and their degradation products in acidic medium and in UV light. Because BZDs are neutral, hydrophobic compounds, the most efficient method proved to be micellar elektrokinetic capillary chromatography (MECC). For the separation we used a sodium tet...
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متن کاملChiral separation of vinpocetine using cyclodextrin-modified micellar electrokinetic chromatography.
A cyclodextrin-modified micellar electrokinetic chromatography (CD-MEKC) technique has been developed for enantioseparation of vinpocetine using an inexpensive 2-hydroxypropyl-β-CD (HP-β-CD) as the chiral selector (CS). The best chiral separation was achieved using 40 mM HP-β-CD as the CS in 50 mM phosphate buffer (pH 7.0) consisting of 40 mM sodium dodecyl sulfate (SDS) at a separation tempera...
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ژورنال
عنوان ژورنال: Croatica Chemica Acta
سال: 2011
ISSN: 0011-1643,1334-417X
DOI: 10.5562/cca1763